Serveur d'exploration MERS

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Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response

Identifieur interne : 001194 ( Main/Exploration ); précédent : 001193; suivant : 001195

Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response

Auteurs : E. Kindler [Suisse] ; V. Thiel [Suisse] ; F. Weber [Allemagne]

Source :

RBID : PMC:7112302

Descripteurs français

English descriptors

Abstract

Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are the most severe coronavirus (CoV)-associated diseases in humans. The causative agents, SARS-CoV and MERS-CoV, are of zoonotic origin but may be transmitted to humans, causing severe and often fatal respiratory disease in their new host. The two coronaviruses are thought to encode an unusually large number of factors that allow them to thrive and replicate in the presence of efficient host defense mechanisms, especially the antiviral interferon system. Here, we review the recent progress in our understanding of the strategies that highly pathogenic coronaviruses employ to escape, dampen, or block the antiviral interferon response in human cells.


Url:
DOI: 10.1016/bs.aivir.2016.08.006
PubMed: 27712625
PubMed Central: 7112302


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<p>Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are the most severe coronavirus (CoV)-associated diseases in humans. The causative agents, SARS-CoV and MERS-CoV, are of zoonotic origin but may be transmitted to humans, causing severe and often fatal respiratory disease in their new host. The two coronaviruses are thought to encode an unusually large number of factors that allow them to thrive and replicate in the presence of efficient host defense mechanisms, especially the antiviral interferon system. Here, we review the recent progress in our understanding of the strategies that highly pathogenic coronaviruses employ to escape, dampen, or block the antiviral interferon response in human cells.</p>
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<li>Allemagne</li>
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</record>

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